Publication
Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study
Martin-Trejo J, Nunez-Enriquez J, Fajardo-Gutierrez A, Medina-Sanson A, Flores-Lujano J, Jimenez-Hernandez E, Amador-Sanchez R, Penaloza-Gonzalez J, Alvarez-Rodriguez F, Bolea-Murga V, Espinosa-Elizondo R, de Diego Flores-Chapa J, Perez-Saldivar M, Rodriguez-Zepeda M, Dorantes-Acosta E, Nunez-Villegas N, Velazquez-Avina M, Torres-Nava J, Reyes-Zepeda N, Gonzalez-Bonilla C, Flores-Villegas L, Rangel-Lopez A, Rivera-Luna R, Paredes-Aguilera R, Cardenas-Cardos R, Martinez-Avalos A, Gil-Hernandez A, Duarte-Rodriguez D, Mejia-Arangure J · Leuk Lymphoma · 2017
The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient's age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08-4.01) was observed in the group of malnourished children with a high-risk ALL.
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